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Resurgence of malaria following discontinuation of indoor residual spraying of insecticide in a previously high transmission intensity area of Uganda.

Raouf, S. and Mpimbaza, A. and Kigozi, R. and Sserwanga, A. and Rubahike, A. and Katamba, H. and Lindsay, S.W. and Kapella, B.K. and Belay, K.A. and Kamya, M.R. and Staedke, S.G. and Dorsey, G. (2017) 'Resurgence of malaria following discontinuation of indoor residual spraying of insecticide in a previously high transmission intensity area of Uganda.', Clinical infectious diseases., 65 (3). pp. 453-460.

Abstract

Background Indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) are the primary tools for malaria prevention in Africa. It is not known whether reductions in malaria can be sustained after IRS is discontinued. The aim of this study was to assess changes in malaria morbidity in a historically high transmission area of Uganda where IRS was discontinued after a four-year period of effective control followed by a universal LLIN distribution campaign. Methods Individual-level malaria surveillance data were collected from one outpatient department and one inpatient setting in Apac District, Uganda from July 2009 through November 2015. Rounds of IRS were delivered approximately every six months from February 2010 through May 2014 followed by universal LLIN distribution in June 2014. Temporal changes in the malaria test positivity rate (TPR) were estimated during and after IRS using interrupted time series analyses, controlling for age, rainfall, and autocorrelation. Results Data include 65,421 outpatient visits and 13,955 pediatric inpatient admissions for which a diagnostic test for malaria was performed. In outpatients under five years, baseline TPR was 60-80% followed by a rapid and then sustained decrease to 15-30%. Over 4-18 months following discontinuation of IRS, absolute TPR values increased by an average of 3.29% per month (95% CI 2.01-4.57%), returning to baseline levels. Similar trends were seen in outpatients over five years of age and pediatric admissions. Conclusions Discontinuation of IRS in a historically high transmission intensity area was associated with a rapid increase in malaria morbidity to pre-IRS levels.

Item Type:Article
Full text:Publisher-imposed embargo until 25 March 2018.
(AM) Accepted Manuscript
First Live Deposit - 10 May 2017
File format - PDF
(377Kb)
Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1093/cid/cix251
Publisher statement:This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical Infectious Diseases following peer review. The version of record Saned Raouf, Arthur Mpimbaza, Ruth Kigozi, Asadu Sserwanga, Denis Rubahika, Henry Katamba, Steve W. Lindsay, Bryan K. Kapella, Kassahun A. Belay, Moses R. Kamya, Sarah G. Staedke, Grant Dorsey (2017) Resurgence of malaria following discontinuation of indoor residual spraying of insecticide in a previously high transmission intensity area of Uganda. Clinical Infectious Diseases, cix251 is available online at: https://doi.org/10.1093/cid/cix251.
Record Created:10 May 2017 10:58
Last Modified:18 Jul 2017 09:38

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