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Cholinergic input to the hippocampus is not required for a model of episodic memory in the rat, even with multiple consecutive events

Seel, S.V.; Eacott, M.J.; Langston, R.F.; Easton, A.

Cholinergic input to the hippocampus is not required for a model of episodic memory in the rat, even with multiple consecutive events Thumbnail


Authors

S.V. Seel

M.J. Eacott

R.F. Langston



Abstract

Previous work has shown that depletion of the cholinergic input to the hippocampus produces no impairment in an episodic (what-where-which) memory task in rats. However, in contrast a where-which task was significantly impaired. Models of acetylcholine function related to pattern separation were used to explain this result. Recent development of spontaneous recognition tasks to assess multiple trials consecutively in the same testing session allow an opportunity to assess whether an increase in interference produces an impairment in the episodic memory task using the same cholinergic lesion. By increasing the number of trials happening consecutively the proactive interference between events being remembered increases, with the prediction that a reduction in pattern separation as a result of reduced acetylcholine in the hippocampus would now produce an impairment in this task. We show that a continual trials approach to the episodic memory task has no impact on the effects of cholinergic depletion of the hippocampus, with effects mirroring those from using just one trial a day approaches to these tasks. We suggest that pattern separation models of acetylcholine function can still explain our findings, but with an apparent emphasis on context-specific locations rather than all types of memory.

Citation

Seel, S., Eacott, M., Langston, R., & Easton, A. (2018). Cholinergic input to the hippocampus is not required for a model of episodic memory in the rat, even with multiple consecutive events. Behavioural Brain Research, 354, 48-54. https://doi.org/10.1016/j.bbr.2017.06.001

Journal Article Type Article
Acceptance Date Jun 1, 2017
Online Publication Date Jun 7, 2017
Publication Date Nov 15, 2018
Deposit Date Jun 22, 2017
Publicly Available Date Mar 29, 2024
Journal Behavioural Brain Research
Print ISSN 0166-4328
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 354
Pages 48-54
DOI https://doi.org/10.1016/j.bbr.2017.06.001

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