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Systems modelling ageing: from single senescent cells to simple multi-cellular models

Martinez Guimera, Alvaro; Welsh, Ciaran; Dalle Pezze, Piero; Fullard, Nicola; Nelson, Glyn; Roger, Mathilde F.; Przyborski, Stefan A.; Shanley, Daryl P.

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Authors

Alvaro Martinez Guimera

Ciaran Welsh

Piero Dalle Pezze

Glyn Nelson

Mathilde F. Roger

Daryl P. Shanley



Abstract

Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.

Citation

Martinez Guimera, A., Welsh, C., Dalle Pezze, P., Fullard, N., Nelson, G., Roger, M., …Shanley, D. (2017). Systems modelling ageing: from single senescent cells to simple multi-cellular models. Essays in Biochemistry, 61(3), 369-377. https://doi.org/10.1042/ebc20160087

Journal Article Type Article
Acceptance Date May 25, 2017
Online Publication Date Jul 11, 2017
Publication Date Jul 11, 2017
Deposit Date Jul 25, 2017
Publicly Available Date Jul 25, 2017
Journal Essays in Biochemistry
Print ISSN 0071-1365
Electronic ISSN 1744-1358
Publisher Portland Press
Peer Reviewed Peer Reviewed
Volume 61
Issue 3
Pages 369-377
DOI https://doi.org/10.1042/ebc20160087

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2017 The Author(s).
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).





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