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MicroRNAs in the skin: role in development, homoeostasis and regeneration

Horsburgh, Steven; Fullard, Nicola; Roger, Mathilde; Degnan, Abbie; Todryk, Stephen; Przyborski, Stefan; O’Reilly, Steven

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Authors

Steven Horsburgh

Mathilde Roger

Abbie Degnan

Stephen Todryk

Steven O’Reilly



Abstract

The skin is the largest organ of the integumentary system and possesses a vast number of functions. Due to the distinct layers of the skin and the variety of cells which populate each, a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability to regulate gene expression via post-transcriptional gene silencing. Of interest, is that a plethora of data demonstrates that a number of miRs are highly expressed within the skin, and are evidently key regulators of numerous vital processes to maintain non-aberrant functioning. Recently, miRs have been targeted as therapeutic interventions due to the ability of synthetic ‘antagomiRs’ to down-regulate abnormal miR expression, thereby potentiating wound healing and attenuating fibrotic processes which can contribute to disease such as systemic sclerosis (SSc). This review will provide an introduction to the structure and function of the skin and miR biogenesis, before summarizing the literature pertaining to the role of miRs. Finally, miR therapies will also be discussed, highlighting important future areas of research.

Citation

Horsburgh, S., Fullard, N., Roger, M., Degnan, A., Todryk, S., Przyborski, S., & O’Reilly, S. (2017). MicroRNAs in the skin: role in development, homoeostasis and regeneration. Clinical Science, 131(15), 1923-1940. https://doi.org/10.1042/cs20170039

Journal Article Type Article
Acceptance Date May 2, 2017
Online Publication Date Jul 13, 2017
Publication Date Jul 13, 2017
Deposit Date Jul 25, 2017
Publicly Available Date Mar 28, 2024
Journal Clinical Science
Print ISSN 0143-5221
Electronic ISSN 1470-8736
Publisher Portland Press
Peer Reviewed Peer Reviewed
Volume 131
Issue 15
Pages 1923-1940
DOI https://doi.org/10.1042/cs20170039

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