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Nuclear pore complex tethers to the cytoskeleton.

Goldberg, Martin W. (2017) 'Nuclear pore complex tethers to the cytoskeleton.', Seminars in cell & developmental biology., 68 . pp. 52-58.

Abstract

The nuclear envelope is tethered to the cytoskeleton. The best known attachments of all elements of the cytoskeleton are via the so-called LINC complex. However, the nuclear pore complexes, which mediate the transport of soluble and membrane bound molecules, are also linked to the microtubule network, primarily via motor proteins (dynein and kinesins) which are linked, most importantly, to the cytoplasmic filament protein of the nuclear pore complex, Nup358, by the adaptor BicD2. The evidence for such linkages and possible roles in nuclear migration, cell cycle control, nuclear transport and cell architecture are discussed.

Item Type:Article
Full text:(AM) Accepted Manuscript
First Live Deposit - 06 September 2017
Available under License - Creative Commons Attribution Non-commercial No Derivatives.
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1016/j.semcdb.2017.06.017
Publisher statement:© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Record Created:06 Sep 2017 12:58
Last Modified:01 Jul 2018 00:59

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