Nuclear pore complex tethers to the cytoskeleton

Goldberg, Martin W.

doi:10.1016/j.semcdb.2017.06.017

Nuclear pore complex tethers to the cytoskeleton

Goldberg, Martin W.

Authors

Professor Martin Goldberg m.w.goldberg@durham.ac.uk
Professor

Abstract

The nuclear envelope is tethered to the cytoskeleton. The best known attachments of all elements of the cytoskeleton are via the so-called LINC complex. However, the nuclear pore complexes, which mediate the transport of soluble and membrane bound molecules, are also linked to the microtubule network, primarily via motor proteins (dynein and kinesins) which are linked, most importantly, to the cytoplasmic filament protein of the nuclear pore complex, Nup358, by the adaptor BicD2. The evidence for such linkages and possible roles in nuclear migration, cell cycle control, nuclear transport and cell architecture are discussed.

Citation

Goldberg, M. W. (2017). Nuclear pore complex tethers to the cytoskeleton. Seminars in Cell and Developmental Biology, 68, 52-58. https://doi.org/10.1016/j.semcdb.2017.06.017

Journal Article Type	Article
Acceptance Date	Jun 23, 2017
Online Publication Date	Jul 1, 2017
Publication Date	Jul 1, 2017
Deposit Date	Jul 24, 2017
Publicly Available Date	Jul 1, 2018
Journal	Seminars in Cell and Developmental Biology
Print ISSN	1084-9521
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	68
Pages	52-58
DOI	https://doi.org/10.1016/j.semcdb.2017.06.017

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Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright Statement
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/