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Bayesian uncertainty analysis for complex systems biology models : emulation, global parameter searches and evaluation of gene functions.

Vernon, Ian and Liu, Junli and Goldstein, Michael and Rowe, James and Topping, Jen and Lindsey, Keith (2018) 'Bayesian uncertainty analysis for complex systems biology models : emulation, global parameter searches and evaluation of gene functions.', BMC systems biology., 12 . p. 1.

Abstract

Many mathematical models have now been employed across every area of systems biology. These models increasingly involve large numbers of unknown parameters, have complex structure which can result in substantial evaluation time relative to the needs of the analysis, and need to be compared to observed data of various forms. The correct analysis of such models usually requires a global parameter search, over a high dimensional parameter space, that incorporates and respects the most important sources of uncertainty. This can be an extremely difficult task, but it is essential for any meaningful inference or prediction to be made about any biological system. It hence represents a fundamental challenge for the whole of systems biology.

Item Type:Article
Full text:(AM) Accepted Manuscript
First Live Deposit - 20 November 2017
Available under License - Creative Commons Attribution.
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Full text:(VoR) Version of Record
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1186/s12918-017-0484-3
Publisher statement:© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Record Created:20 Nov 2017 09:58
Last Modified:17 Jan 2018 15:09

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