Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents

Marsh, James W.; Djoko, Karrera Y.; McEwan, Alastair G.; Huston, Wilhelmina M.

doi:10.1093/femspd/ftx084

Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents

Marsh, James W.; Djoko, Karrera Y.; McEwan, Alastair G.; Huston, Wilhelmina M.

Authors

James W. Marsh

Dr Karrera Djoko karrera.djoko@durham.ac.uk
Associate Professor

Alastair G. McEwan

Wilhelmina M. Huston

Abstract

Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny. Impacts on host cell viability and respiration were also observed in addition to the Chlamydia impacts. This work suggests that copper-based complexes may represent a new lead approach for future development of new therapeutics against chlamydial infections, although host cell impacts need to be fully explored.

Citation

Marsh, J. W., Djoko, K. Y., McEwan, A. G., & Huston, W. M. (2017). Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents. Pathogens and Disease, 75(7), Article ftx084. https://doi.org/10.1093/femspd/ftx084

Journal Article Type	Article
Acceptance Date	Jul 20, 2017
Online Publication Date	Jul 24, 2017
Publication Date	Sep 29, 2017
Deposit Date	Sep 6, 2017
Publicly Available Date	Jul 24, 2018
Journal	Pathogens and Disease
Publisher	Oxford University Press
Peer Reviewed	Peer Reviewed
Volume	75
Issue	7
Article Number	ftx084
DOI	https://doi.org/10.1093/femspd/ftx084

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Copyright Statement
This is a pre-copyedited, author-produced version of an article accepted for publication in Pathogens and Disease following peer review. The version of record James W. Marsh, Karrera Y. Djoko, Alastair G. McEwan, Wilhelmina M. Huston (2017) Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents, Pathogens and Disease, 75(7), ftx084 is available online at: https://doi.org/10.1093/femspd/ftx084.