Synthesis of β-fluoro(dicarbonyl)ethylamines from 2-fluoro-ethylacetoacetate and dimethyl-2-fluoromalonate ester by batch and semi-continuous flow three-component Mannich reactions

Lisse, Etienne; Sandford, Graham

doi:10.1016/j.jfluchem.2017.12.012

Synthesis of β-fluoro(dicarbonyl)ethylamines from 2-fluoro-ethylacetoacetate and dimethyl-2-fluoromalonate ester by batch and semi-continuous flow three-component Mannich reactions

Lisse, Etienne; Sandford, Graham

Authors

Etienne Lisse

Graham Sandford

Abstract

Multi-component Mannich reactions between 2-fluoro-ethylacetoacetate or dimethyl-2-fluoromalonate ester, aldehyde and amine components allowing convenient synthesis of β-fluoro(dicarbonyl)ethylamine systems using both batch and continuous flow techniques are reported.

Citation

Lisse, E., & Sandford, G. (2018). Synthesis of β-fluoro(dicarbonyl)ethylamines from 2-fluoro-ethylacetoacetate and dimethyl-2-fluoromalonate ester by batch and semi-continuous flow three-component Mannich reactions. Journal of Fluorine Chemistry, 206, 117-124. https://doi.org/10.1016/j.jfluchem.2017.12.012

Journal Article Type	Article
Acceptance Date	Dec 19, 2017
Online Publication Date	Dec 20, 2017
Publication Date	Feb 1, 2018
Deposit Date	Jan 3, 2018
Publicly Available Date	Dec 20, 2018
Journal	Journal of Fluorine Chemistry
Print ISSN	0022-1139
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	206
Pages	117-124
DOI	https://doi.org/10.1016/j.jfluchem.2017.12.012

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http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright Statement
© 2017 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/