Small-Molecule Povidone Analogs in Coamorphous Pharmaceutical Phases

Goodwin, Melissa; Musa, Osama; Berry, David; Steed, Jonathan W.

doi:10.1021/acs.cgd.7b01062

Small-Molecule Povidone Analogs in Coamorphous Pharmaceutical Phases

Goodwin, Melissa; Musa, Osama; Berry, David; Steed, Jonathan W.

Authors

Melissa Goodwin

Osama Musa

David Berry

Professor Jonathan Steed jon.steed@durham.ac.uk
Professor

Abstract

The crystallization inhibitor polyvinylpyrrolidone (PVP) is commonly used as a stabilizer in the formation of amorphous polymer dispersions of poorly soluble pharmaceuticals. In this work we examine the use of a range of PVP-inspired small-molecule bis(lactams) as coformers in the stabilization of amorphous pharmaceutical phases creating coamorphous materials. The dimer of N-vinyl(caprolactam) (bisVCap, 3) was found to be an effective coamorphous-former at relatively low loading for carisoprodol, carbamazepine, isoniazid, and 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY).

Citation

Goodwin, M., Musa, O., Berry, D., & Steed, J. W. (2018). Small-Molecule Povidone Analogs in Coamorphous Pharmaceutical Phases. Crystal Growth and Design, 18(2), 701-709. https://doi.org/10.1021/acs.cgd.7b01062

Journal Article Type	Article
Acceptance Date	Dec 18, 2017
Online Publication Date	Jan 4, 2018
Publication Date	Feb 7, 2018
Deposit Date	Jan 5, 2018
Publicly Available Date	Jan 4, 2019
Journal	Crystal Growth and Design
Print ISSN	1528-7483
Electronic ISSN	1528-7505
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	18
Issue	2
Pages	701-709
DOI	https://doi.org/10.1021/acs.cgd.7b01062

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that will appear in final form in Crystal growth & design, copyright © American Chemical Society after peer review and technical editing by the publisher.