Cookies

We use cookies to ensure that we give you the best experience on our website. By continuing to browse this repository, you give consent for essential cookies to be used. You can read more about our Privacy and Cookie Policy.


Durham Research Online
You are in:

malERA : an updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication.

Elimination, The malERA Refresh Consultative Panel on Tools for Malaria (2017) 'malERA : an updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication.', PLoS medicine., 14 (11). e1002455.

Abstract

Since the turn of the century, a remarkable expansion has been achieved in the range and effectiveness of products and strategies available to prevent, treat, and control malaria, including advances in diagnostics, drugs, vaccines, and vector control. These advances have once again put malaria elimination on the agenda. However, it is clear that even with the means available today, malaria control and elimination pose a formidable challenge in many settings. Thus, currently available resources must be used more effectively, and new products and approaches likely to achieve these goals must be developed. This paper considers tools (both those available and others that may be required) to achieve and maintain malaria elimination. New diagnostics are needed to direct treatment and detect transmission potential; new drugs and vaccines to overcome existing resistance and protect against clinical and severe disease, as well as block transmission and prevent relapses; and new vector control measures to overcome insecticide resistance and more powerfully interrupt transmission. It is also essential that strategies for combining new and existing approaches are developed for different settings to maximise their longevity and effectiveness in areas with continuing transmission and receptivity. For areas where local elimination has been recently achieved, understanding which measures are needed to maintain elimination is necessary to prevent rebound and the reestablishment of transmission. This becomes increasingly important as more countries move towards elimination.

Item Type:Article
Full text:(VoR) Version of Record
First Live Deposit - 11 January 2018
Available under License - Creative Commons Attribution.
Download PDF
(3036Kb)
Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1371/journal.pmed.1002455
Publisher statement:Copyright: © 2017 The malERA Consultative Panel on Tools for Malaria Elimination. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Record Created:11 Jan 2018 15:43
Last Modified:11 Jan 2018 16:29

Social bookmarking: del.icio.usConnoteaBibSonomyCiteULikeFacebookTwitterExport: EndNote, Zotero | BibTex
Look up in GoogleScholar | Find in a UK Library