Tailored Supramolecular Gel and Microemulsion Crystallization Strategies – is Isoniazid Really Monomorphic?

Kennedy, Stuart R.; Jones, Christopher D.; Yufit, Dimitrii S.; Nicholson, Catherine Emma; Cooper, Sharon J.; Steed, Jonathan W.

doi:10.1039/c8ce00066b

Tailored Supramolecular Gel and Microemulsion Crystallization Strategies – is Isoniazid Really Monomorphic?

Kennedy, Stuart R.; Jones, Christopher D.; Yufit, Dimitrii S.; Nicholson, Catherine Emma; Cooper, Sharon J.; Steed, Jonathan W.

Authors

Stuart R. Kennedy

Christopher D. Jones

Dimitrii S. Yufit

Catherine Emma Nicholson

Professor Sharon Cooper sharon.cooper@durham.ac.uk
Professor

Professor Jonathan Steed jon.steed@durham.ac.uk
Professor

Abstract

We report the application of supramolecular gel and microemulsion droplet crystallisation methodologies to isoniazid crystallization. Tailored gelators have been designed with isoniazid mimetic functionality in an attempt to control crystal morphology and polymorphic behaviour. Microemulsion crystallisation was investigated to achieve thermodynamic control over drug crystallisation. Both techniques resulted in only a single form of isoniazid implying that it is genuinely monomorphic.

Citation

Kennedy, S. R., Jones, C. D., Yufit, D. S., Nicholson, C. E., Cooper, S. J., & Steed, J. W. (2018). Tailored Supramolecular Gel and Microemulsion Crystallization Strategies – is Isoniazid Really Monomorphic?. CrystEngComm, 20(10), 1390-1398. https://doi.org/10.1039/c8ce00066b

Journal Article Type	Article
Acceptance Date	Feb 10, 2018
Online Publication Date	Feb 12, 2018
Publication Date	Mar 14, 2018
Deposit Date	Feb 13, 2018
Publicly Available Date	Feb 10, 2019
Journal	CrystEngComm
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	20
Issue	10
Pages	1390-1398
DOI	https://doi.org/10.1039/c8ce00066b