Tuning Mg2+ selectivity: comparative analysis of the photophysical properties of four fluorescent probes with an alkynyl-naphthalene fluorophore

Parker, D.; Williams, J.A.G.; Walter, E.R.H.

doi:10.1002/chem.201800013

Tuning Mg2+ selectivity: comparative analysis of the photophysical properties of four fluorescent probes with an alkynyl-naphthalene fluorophore

Parker, D.; Williams, J.A.G.; Walter, E.R.H.

Authors

Professor David Parker david.parker@durham.ac.uk
Emeritus Professor

Professor Gareth Williams j.a.g.williams@durham.ac.uk
Professor

E.R.H. Walter

Abstract

Four alkynyl‐1‐naphthyl fluorophores have been synthesised with tri‐ or pentadentate ligating groups suited to the binding of magnesium. Their photophysical and binding properties for magnesium, calcium and zinc ions have been assessed using absorption, emission and excitation spectroscopy. Each compound has a pKa value between 6.2 and 5.1 and exhibits no significant pH response around pH 7.2. Enhanced selectivity for Mg2+ over Ca2+ was observed with a pentadentate phosphinate substituted system, compared to its carboxylate analogue, due to a 10‐fold lowering of affinity for the Ca2+ ion. In each case, the overall dissociation constants for Mg2+ fall in the low mM range.

Citation

Parker, D., Williams, J., & Walter, E. (2018). Tuning Mg2+ selectivity: comparative analysis of the photophysical properties of four fluorescent probes with an alkynyl-naphthalene fluorophore. Chemistry - A European Journal, 24(24), 6432-6441. https://doi.org/10.1002/chem.201800013

Journal Article Type	Article
Acceptance Date	Feb 28, 2018
Online Publication Date	Jan 28, 2018
Publication Date	Apr 14, 2018
Deposit Date	Mar 22, 2018
Publicly Available Date	Apr 14, 2019
Journal	Chemistry - A European Journal
Print ISSN	0947-6539
Electronic ISSN	1521-3765
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	24
Issue	24
Pages	6432-6441
DOI	https://doi.org/10.1002/chem.201800013

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Copyright Statement
This is the peer reviewed version of the following article: Parker, D., Williams, J. A. G. & Walter, E. R. H. (2018). Tuning Mg2+ selectivity: comparative analysis of the photophysical properties of four fluorescent probes with an alkynyl-naphthalene fluorophore. Chemistry - A European Journal, which has been published in final form at https://doi.org/10.1002/chem.201800013. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving.