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Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence.

Parker, David and Shuvaev, Sergey and Fox, Mark A. (2018) 'Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence.', Angewandte chemie international edition., 57 (25). pp. 7488-7492.

Abstract

A series of three europium complexes is reported bearing picolyl amine moieties with different substituents, that possess differing binding affinities towards Zn2+ and three nucleotides ‐ AMP, ADP and ATP. A large increase of the total emission intensity was observed upon binding Zn2+, followed by further signal amplification upon addition of nucleotides. The resulting adducts possess strong induced circularly polarised emission, with ADP and ATP signals being of opposite sign. Model DFT geometries of the adducts suggest the Δ diastereoisomer is preferred for ATP and the Λ isomer for ADP/AMP. Such a change in sign allows the ADP:/ATP (or AMP/ATP) ratio to be assessed by monitoring changes in the emission dissymmetry factor, gem.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1002/anie.201801248
Publisher statement:This is the accepted version of the following article: Parker, David, Shuvaev, Sergey & Fox, Mark A. (2018). Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence. Angewandte Chemie International Edition, 57(25): 7488-7492, which has been published in final form at https://doi.org/10.1002/anie.201801248. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Date accepted:27 March 2018
Date deposited:28 March 2018
Date of first online publication:30 March 2018
Date first made open access:30 March 2019

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