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Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence

Parker, David; Shuvaev, Sergey; Fox, Mark A.

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Authors

Sergey Shuvaev



Abstract

A series of three europium complexes is reported bearing picolyl amine moieties with different substituents, that possess differing binding affinities towards Zn2+ and three nucleotides ‐ AMP, ADP and ATP. A large increase of the total emission intensity was observed upon binding Zn2+, followed by further signal amplification upon addition of nucleotides. The resulting adducts possess strong induced circularly polarised emission, with ADP and ATP signals being of opposite sign. Model DFT geometries of the adducts suggest the Δ diastereoisomer is preferred for ATP and the Λ isomer for ADP/AMP. Such a change in sign allows the ADP:/ATP (or AMP/ATP) ratio to be assessed by monitoring changes in the emission dissymmetry factor, gem.

Citation

Parker, D., Shuvaev, S., & Fox, M. A. (2018). Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence. Angewandte Chemie International Edition, 57(25), 7488-7492. https://doi.org/10.1002/anie.201801248

Journal Article Type Article
Acceptance Date Mar 27, 2018
Online Publication Date Mar 30, 2018
Publication Date Jun 11, 2018
Deposit Date Mar 28, 2018
Publicly Available Date Mar 28, 2024
Journal Angewandte Chemie International Edition
Print ISSN 1433-7851
Electronic ISSN 1521-3773
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 57
Issue 25
Pages 7488-7492
DOI https://doi.org/10.1002/anie.201801248

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Copyright Statement
This is the accepted version of the following article: Parker, David, Shuvaev, Sergey & Fox, Mark A. (2018). Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence. Angewandte Chemie International Edition, 57(25): 7488-7492, which has been published in final form at https://doi.org/10.1002/anie.201801248. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.




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