A Direct Route for the Preparation of Fmoc/OtBu Protected Iodotyrosine

Steer, A.M.; Bolt, H.L.; Brittain, W.D.G.; Cobb, S.L.

doi:10.1016/j.tetlet.2018.05.061

A Direct Route for the Preparation of Fmoc/OtBu Protected Iodotyrosine

Steer, A.M.; Bolt, H.L.; Brittain, W.D.G.; Cobb, S.L.

Authors

A.M. Steer

H.L. Bolt

Dr Will Brittain william.d.brittain@durham.ac.uk
Assistant Professor

Professor Steven Cobb s.l.cobb@durham.ac.uk
Professor

Abstract

Herein the synthesis of an Fmoc/OtBu orthogonally protected iodotyrosine derivative is reported. This has been achieved via a simple two-step process in an overall 58% yield from commercially available Fmoc-Tyr(tBu)-OH. The Fmoc/OtBu orthogonally protected iodotyrosine was also shown to be amenable to Suzuki-Miyaura cross-coupling to deliver a novel bi-aryl tyrosine derivative.

Citation

Steer, A., Bolt, H., Brittain, W., & Cobb, S. (2018). A Direct Route for the Preparation of Fmoc/OtBu Protected Iodotyrosine. Tetrahedron Letters, 59(27), 2644-2646. https://doi.org/10.1016/j.tetlet.2018.05.061

Journal Article Type	Article
Acceptance Date	May 22, 2018
Online Publication Date	May 23, 2018
Publication Date	Jul 4, 2018
Deposit Date	May 22, 2018
Publicly Available Date	May 29, 2018
Journal	Tetrahedron Letters
Print ISSN	0040-4039
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	59
Issue	27
Pages	2644-2646
DOI	https://doi.org/10.1016/j.tetlet.2018.05.061

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http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).