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Dynamic morphologies and stability of droplet interface bilayers

Guiselin, B.; Law, J.O.; Chakrabarti, B.; Kusumaatmaja, H.

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Authors

B. Guiselin

J.O. Law

B. Chakrabarti



Abstract

We develop a theoretical framework for understanding dynamic morphologies and stability of droplet interface bilayers (DIBs), accounting for lipid kinetics in the monolayers and bilayer, and droplet evaporation due to imbalance between osmotic and Laplace pressures. Our theory quantitatively describes distinct pathways observed in experiments when DIBs become unstable. We find that when the timescale for lipid desorption is slow compared to droplet evaporation, the lipid bilayer will grow and the droplets approach a hemispherical shape. In contrast, when lipid desorption is fast, the bilayer area will shrink and the droplets eventually detach. Our model also suggests there is a critical size below which DIBs can become unstable, which may explain experimental difficulties in miniaturizing the DIB platform.

Citation

Guiselin, B., Law, J., Chakrabarti, B., & Kusumaatmaja, H. (2018). Dynamic morphologies and stability of droplet interface bilayers. Physical Review Letters, 120(23), Article 238001. https://doi.org/10.1103/physrevlett.120.238001

Journal Article Type Article
Acceptance Date May 7, 2018
Online Publication Date Jun 6, 2018
Publication Date Jun 6, 2018
Deposit Date May 30, 2018
Publicly Available Date Mar 28, 2024
Journal Physical Review Letters
Print ISSN 0031-9007
Electronic ISSN 1079-7114
Publisher American Physical Society
Peer Reviewed Peer Reviewed
Volume 120
Issue 23
Article Number 238001
DOI https://doi.org/10.1103/physrevlett.120.238001
Related Public URLs https://arxiv.org/abs/1803.08262

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Copyright Statement
Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.





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