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Prediction of gene expression in human using rat in vivo gene expression in Japanese Toxicogenomics Project.

Otava, M. and Shkedy, Z. and Kasim, A. (2014) 'Prediction of gene expression in human using rat in vivo gene expression in Japanese Toxicogenomics Project.', Systems biomedicine., 2 (1). pp. 8-15.

Abstract

The Japanese Toxicogenomics Project (TGP) provides large amount of data for the toxicology and safety framework. We focus on gene expression data of rat in vivo and human in vitro. We consider two different analyses for the TGP data. The first analysis is based on two-way analysis of variance model and the goal is to detect genes with significant dose-response relationship in both humans and rats. The second analysis consists of a trend analysis at each time point and the goal is to detect genes in the rat in order to predict gene expression in humans. The first analysis leads us to conclusions about the heterogeneity of the compound set and will suggest how to address this issue to improve future analyses. In the second part, we identify, for particular compounds, groups of genes that are translatable from rats to humans, so they can be used for prediction of human in vitro data based on rat in vivo data.

Item Type:Article
Full text:(VoR) Version of Record
First Live Deposit - 13 June 2018
Available under License - Creative Commons Attribution Non-commercial.
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.4161/sysb.29412
Publisher statement:© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC© Martin Otava, Ziv Shkedy, and Adetayo Kasim This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
Record Created:12 Jun 2018 16:58
Last Modified:13 Jun 2018 11:20

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