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Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology

Bolt, Hannah; Kleijn, Laurens; Martin, Nathaniel; Cobb, Steven

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Authors

Hannah Bolt

Laurens Kleijn

Nathaniel Martin



Abstract

Antimicrobial peptides and structurally related peptoids offer potential for the development of new antibiotics. However, progress has been hindered by challenges presented by poor in vivo stability (peptides) or lack of selectivity (peptoids). Herein, we have developed a process to prepare novel hybrid antibacterial agents that combine both linear peptoids (increased in vivo stability compared to peptides) and a nisin fragment (lipid II targeting domain). The hybrid nisin–peptoids prepared were shown to have low micromolar activity (comparable to natural nisin) against methicillin-resistant Staphylococcus aureus.

Citation

Bolt, H., Kleijn, L., Martin, N., & Cobb, S. (2018). Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology. Molecules, 23(7), Article 1566. https://doi.org/10.3390/molecules23071566

Journal Article Type Article
Acceptance Date Jun 21, 2018
Online Publication Date Jun 28, 2018
Publication Date Jun 28, 2018
Deposit Date Jul 12, 2018
Publicly Available Date Mar 28, 2024
Journal Molecules
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 23
Issue 7
Article Number 1566
DOI https://doi.org/10.3390/molecules23071566

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Published Journal Article (1 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).





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