Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

Clulow, James A.; Storck, Elisabeth M.; Lanyon-Hogg, Thomas; Kalesh, Karunakaran A.; Jones, Lyn H.; Tate, Edward W.

doi:10.1039/c6cc08797c

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

Clulow, James A.; Storck, Elisabeth M.; Lanyon-Hogg, Thomas; Kalesh, Karunakaran A.; Jones, Lyn H.; Tate, Edward W.

Authors

James A. Clulow

Elisabeth M. Storck

Thomas Lanyon-Hogg

Karunakaran A. Kalesh

Lyn H. Jones

Edward W. Tate

Contributors

Dr Kalesh Karunakaran Nair Anandamma kalesh.karunakaran@durham.ac.uk
Other

Abstract

Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane’s targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane’s bioactivity, and aid understanding of its complex mode of action.

Citation

Clulow, J. A., Storck, E. M., Lanyon-Hogg, T., Kalesh, K. A., Jones, L. H., & Tate, E. W. (2017). Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chemical Communications, 53(37), 5182-5185. https://doi.org/10.1039/c6cc08797c

Journal Article Type	Article
Acceptance Date	Apr 13, 2017
Online Publication Date	Apr 25, 2017
Publication Date	Apr 25, 2017
Deposit Date	Jan 29, 2019
Publicly Available Date	Apr 16, 2019
Journal	Chemical Communications
Print ISSN	1359-7345
Electronic ISSN	1364-548X
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	53
Issue	37
Pages	5182-5185
DOI	https://doi.org/10.1039/c6cc08797c
Related Public URLs	https://spiral.imperial.ac.uk/handle/10044/1/48122