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Near Infrared Light Activates Molecular Nanomachines to Drill Into and Kill Cells

Liu, Dongdong; García-López, Víctor; Gunasekera, Richard S.; Greer Nilewski, Lizanne; Alemany, Lawrence B.; Aliyan, Amir; Jin, Tao; Wang, Gufeng; Tour, James M.; Pal, Robert

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Authors

Dongdong Liu

Víctor García-López

Richard S. Gunasekera

Lizanne Greer Nilewski

Lawrence B. Alemany

Amir Aliyan

Tao Jin

Gufeng Wang

James M. Tour



Abstract

Using two-photon excitation (2PE), molecular nanomachines (MNMs) are able to drill through cell membranes and kill the cells. This avoids the use of the more damaging ultraviolet (UV) light that has been used formerly to induce this nanomechanical cell-killing effect. Since 2PE is inherently confocal, enormous precision can be realized. The MNMs can be targeted to specific cell surfaces through peptide addends. Further, the efficacy was verified through controlled opening of synthetic bilayer vesicles using the 2PE excitation of MNM that had been trapped within the vesicles.

Citation

Liu, D., García-López, V., Gunasekera, R. S., Greer Nilewski, L., Alemany, L. B., Aliyan, A., …Pal, R. (2019). Near Infrared Light Activates Molecular Nanomachines to Drill Into and Kill Cells. ACS Nano, 13(6), 6813-6823. https://doi.org/10.1021/acsnano.9b01556

Journal Article Type Article
Acceptance Date May 21, 2019
Online Publication Date May 22, 2019
Publication Date Jun 25, 2019
Deposit Date May 24, 2019
Publicly Available Date Mar 28, 2024
Journal ACS Nano
Print ISSN 1936-0851
Electronic ISSN 1936-086X
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 13
Issue 6
Pages 6813-6823
DOI https://doi.org/10.1021/acsnano.9b01556

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS nano copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.9b01556





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