C-H activation/metalation approaches for the synthesis of indolizine derivatives

Clososki, Giuliano Cesar; Steel, Patrick G.; Bertallo, Camila Rodrigues de Souza; Arroio, Thaís Rodrigues Arroio Rodrigues; Vessecchi, Ricardo; Toledo, Monica F.Z.J.; Sadler, Scott

doi:10.1002/ejoc.201900608

C-H activation/metalation approaches for the synthesis of indolizine derivatives

Clososki, Giuliano Cesar; Steel, Patrick G.; Bertallo, Camila Rodrigues de Souza; Arroio, Thaís Rodrigues Arroio Rodrigues; Vessecchi, Ricardo; Toledo, Monica F.Z.J.; Sadler, Scott

Authors

Giuliano Cesar Clososki

Professor Patrick Steel p.g.steel@durham.ac.uk
Professor

Camila Rodrigues de Souza Bertallo

Thaís Rodrigues Arroio Rodrigues Arroio

Ricardo Vessecchi

Monica F.Z.J. Toledo

Scott Sadler

Abstract

The C‐H borylation of indolizines has not previously been reported and in this communication, we describe our preliminary efforts to apply this chemistry to this scaffold and contrast this approach to directed metalation. Through these methodologies were possible obtain a library of substituted indolizines functionalized in both pyridinic and pyrrole ring.

Citation

Clososki, G. C., Steel, P. G., Bertallo, C. R. D. S., Arroio, T. R. A. R., Vessecchi, R., Toledo, M. F., & Sadler, S. (2019). C-H activation/metalation approaches for the synthesis of indolizine derivatives. European Journal of Organic Chemistry, 31-32, 5205-5213. https://doi.org/10.1002/ejoc.201900608

Journal Article Type	Article
Acceptance Date	Jun 5, 2019
Publication Date	Sep 30, 2019
Deposit Date	Jun 6, 2019
Publicly Available Date	Jun 25, 2020
Journal	European Journal of Organic Chemistry
Print ISSN	1434-193X
Electronic ISSN	1099-0690
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	31-32
Pages	5205-5213
DOI	https://doi.org/10.1002/ejoc.201900608

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Copyright Statement
This is the accepted version of the following article: Clososki, Giuliano Cesar, Steel, Patrick G., Bertallo, Camila Rodrigues de Souza, Arroio, Thaís Rodrigues Arroio Rodrigues, Vessecchi, Ricardo, Toledo, Monica F. Z. J. & Sadler, Scott (2019). C-H activation/metalation approaches for the synthesis of indolizine derivatives. European Journal of Organic Chemistry 31-32: 5205-5213 which has been published in final form at https://doi.org/10.1002/ejoc.201900608. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.