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To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions

Arnold, K.; Davies, B.; Giles, R.L.; Grosjean, C.; Smith, G.E.; Whiting, A.

Authors

K. Arnold

B. Davies

R.L. Giles

C. Grosjean

G.E. Smith



Abstract

Kinetic studies show that the direct formation of amides from amines and carboxylic acids without catalyst does occur under relatively low temperature conditions, but is highly substrate dependent. Boric and boronic acid-based catalysts improve the reaction, especially for less reactive acids, and initial results indicate that bifunctional catalysts show even greater potential.

Citation

Arnold, K., Davies, B., Giles, R., Grosjean, C., Smith, G., & Whiting, A. (2006). To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions. Advanced Synthesis & Catalysis, 348(7-8), 813-820. https://doi.org/10.1002/adsc.200606018

Journal Article Type Article
Publication Date May 5, 2006
Deposit Date Apr 10, 2007
Journal Advanced Synthesis & Catalysis
Print ISSN 1615-4150
Electronic ISSN 1615-4169
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 348
Issue 7-8
Pages 813-820
DOI https://doi.org/10.1002/adsc.200606018
Keywords Amines, Bifunctional catalysis, Boronate catalysis, Carboxylic acids, Direct amide formation, Green catalysis.