Arnold, K. and Davies, B. and Giles, R. L. and Grosjean, C. and Smith, G. E. and Whiting, A. (2006) 'To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions.', Advanced synthesis and catalysis., 348 (7-8). pp. 813-820.
Kinetic studies show that the direct formation of amides from amines and carboxylic acids without catalyst does occur under relatively low temperature conditions, but is highly substrate dependent. Boric and boronic acid-based catalysts improve the reaction, especially for less reactive acids, and initial results indicate that bifunctional catalysts show even greater potential.
|Keywords:||Amines, Bifunctional catalysis, Boronate catalysis, Carboxylic acids, Direct amide formation, Green catalysis.|
|Full text:||Full text not available from this repository.|
|Publisher Web site:||http://dx.doi.org/10.1002/adsc.200606018|
|Record Created:||10 Apr 2007|
|Last Modified:||24 Sep 2015 14:06|
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