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Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group

Meksawangwong, Sureemas; Gohil, Bhavini; Punyain, Wikorn; Pal, Robert; Kielar, Filip

Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group Thumbnail


Authors

Sureemas Meksawangwong

Bhavini Gohil

Wikorn Punyain

Filip Kielar



Abstract

A novel tris-cyclometalated iridium complex (1) containing a single quarternary ammonium moiety has been synthesized, characterized, and investigated as a potential cellular imaging probe. The complex is the next generation of the aminoalkyl iridium complexes recently published by our group. The complex possesses outstanding photophysical properties. The complex is stable in solution in dark but exhibits rapid photocatalyzed transformations. Investigations of this behavior have shown that these transformations involve the formation of an electrophilic species, which can be captured by a suitable nucleophile, leading to the formation of new product. The complex has also been investigated as a potential cellular stain. It is less cytotoxic than its aminoalkyl predecessor and shows lysosomal localization as its precursor.

Citation

Meksawangwong, S., Gohil, B., Punyain, W., Pal, R., & Kielar, F. (2019). Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group. Inorganica Chimica Acta, 497, Article 119066. https://doi.org/10.1016/j.ica.2019.119066

Journal Article Type Article
Acceptance Date Aug 8, 2019
Online Publication Date Aug 10, 2019
Publication Date Nov 1, 2019
Deposit Date Sep 2, 2019
Publicly Available Date Aug 10, 2020
Journal Inorganica Chimica Acta
Print ISSN 0020-1693
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 497
Article Number 119066
DOI https://doi.org/10.1016/j.ica.2019.119066

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