G. Sandford
Tetrahydropyrido 3,4-b pyrazine scaffolds from pentafluoropyridine
Sandford, G.; Slater, R.; Yufit, D.S.; Howard, J.A.K.; Vong, A.
Authors
R. Slater
D.S. Yufit
J.A.K. Howard
A. Vong
Abstract
Representative polyfunctional tetrahydropyrido[3,4-b]pyrazine scaffolds have been synthesized very readily by a one-pot annelation reaction of pentafluoropyridine with appropriate diamines. The trifluorinated pyridopyrazine products react sequentially with various nucleophiles to give polysubstituted tetrahydropyridopyrazines, demonstrating the potential of the polyfluorinated ring fused pyridine system as a scaffold for the synthesis of previously inaccessible polysubstituted pyridopyrazine derivatives. This general approach has special relevance to the development of new chemical entities for the life science industries and particularly in the drug discovery arena, in which low molecular weight, polyfunctional heterocyclic derivatives are playing an increasingly important role.
Citation
Sandford, G., Slater, R., Yufit, D., Howard, J., & Vong, A. (2005). Tetrahydropyrido 3,4-b pyrazine scaffolds from pentafluoropyridine. Journal of Organic Chemistry, 70(18), 7208-7216. https://doi.org/10.1021/jo0508696
Journal Article Type | Article |
---|---|
Publication Date | 2005-08 |
Deposit Date | Apr 20, 2007 |
Journal | Journal of Organic Chemistry |
Print ISSN | 0022-3263 |
Electronic ISSN | 1520-6904 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 70 |
Issue | 18 |
Pages | 7208-7216 |
DOI | https://doi.org/10.1021/jo0508696 |
You might also like
HFO-1234yf as a CF3-building block: Synthesis and Chemistry of CF3-ynones
(2020)
Journal Article
Kinetics of electrophilic fluorination of steroids and epimerisation of fluorosteroids
(2020)
Journal Article
Fluorocyanoesters as Additives for Lithium-Ion Battery Electrolytes
(2020)
Journal Article