Far From Inert: Membrane Lipids Possess Intrinsic Reactivity That Has Consequences For Cell Biology

Sanderson, John M

doi:10.1002/bies.201900147

Far From Inert: Membrane Lipids Possess Intrinsic Reactivity That Has Consequences For Cell Biology

Sanderson, John M

Authors

Dr John Sanderson j.m.sanderson@durham.ac.uk
Associate Professor

Abstract

In this article, it is hypothesized that a fundamental chemical reactivity exists between some non‐lipid constituents of cellular membranes and ester‐based lipids, the significance of which is not generally recognized. Many peptides and smaller organic molecules have now been shown to undergo lipidation reactions in model membranes in circumstances where direct reaction with the lipid is the only viable route for acyl transfer. Crucially, drugs like propranolol are lipidated in vivo with product profiles that are comparable to those produced in vitro. Some compounds have also been found to promote lipid hydrolysis. Drugs with high lytic activity in vivo tend to have higher toxicity in vitro. Deacylases and lipases are proposed as key enzymes that protect cells against the effects of intrinsic lipidation. The toxic effects of intrinsic lipidation are hypothesized to include a route by which nucleation can occur during the formation of amyloid fibrils.

Citation

Sanderson, J. M. (2020). Far From Inert: Membrane Lipids Possess Intrinsic Reactivity That Has Consequences For Cell Biology. BioEssays, 42(3), Article 1900147. https://doi.org/10.1002/bies.201900147

Journal Article Type	Article
Acceptance Date	Dec 12, 2019
Online Publication Date	Jan 29, 2020
Publication Date	Mar 31, 2020
Deposit Date	Dec 16, 2019
Publicly Available Date	Jan 29, 2021
Journal	BioEssays
Print ISSN	0265-9247
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	42
Issue	3
Article Number	1900147
DOI	https://doi.org/10.1002/bies.201900147

Files

Accepted Journal Article (2 Mb)
PDF

Copyright Statement
This is the accepted version of the following article: Sanderson, John M (2020). Far From Inert: Membrane Lipids Possess Intrinsic Reactivity That Has Consequences For Cell Biology. BioEssays 42(3): 1900147 which has been published in final form at https://doi.org/10.1002/bies.201900147. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.