SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth

Srivastava, Moumita; Srivastava, Anjil K.; Orosa-Puente, Beatriz; Campanaro, Alberto; Zhang, Cunjin; Sadanandom, Ari

doi:10.1016/j.cub.2020.01.089

SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth

Srivastava, Moumita; Srivastava, Anjil K.; Orosa-Puente, Beatriz; Campanaro, Alberto; Zhang, Cunjin; Sadanandom, Ari

Authors

Moumita Srivastava

Anjil K. Srivastava

Beatriz Orosa-Puente

Alberto Campanaro

Dr Cunjin Zhang cunjin.zhang@durham.ac.uk
Senior Experimental Officer

Professor Ari Sadanandom ari.sadanandom@durham.ac.uk
Professor

Contributors

AK Srivastava a.k.srivastava@durham.ac.uk
Other

B Orosa hrzs77@durham.ac.uk
Other

Abstract

Brassinosteroids (BRs) play crucial roles in plant development, but little is known of mechanisms that integrate environmental cues into BR signaling. Conjugation to the small ubiquitin-like modifier (SUMO) is emerging as an important mechanism to transduce environmental cues into cellular signaling. In this study, we show that SUMOylation of BZR1, a key transcription factor of BR signaling, provides a conduit for environmental influence to modulate growth during stress. SUMOylation stabilizes BZR1 in the nucleus by inhibiting its interaction with BIN2 kinase. During salt stress, Arabidopsis plants arrest growth through deSUMOylation of BZR1 in the cytoplasm by promoting the accumulation of the BZR1 targeting SUMO protease, ULP1a. ULP1a mutants are salt tolerant and insensitive to the BR inhibitor, brassinazole. BR treatment stimulates ULP1a degradation, allowing SUMOylated BZR1 to accumulate and promote growth. This study uncovers a mechanism for integrating environmental cues into BR signaling to shape growth.

Citation

Srivastava, M., Srivastava, A. K., Orosa-Puente, B., Campanaro, A., Zhang, C., & Sadanandom, A. (2020). SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth. Current Biology, 30(8), 1423.e3-1423.e3. https://doi.org/10.1016/j.cub.2020.01.089

Journal Article Type	Article
Acceptance Date	Jan 30, 2020
Online Publication Date	Feb 27, 2020
Publication Date	Apr 20, 2020
Deposit Date	Feb 28, 2020
Publicly Available Date	Feb 28, 2020
Journal	Current Biology
Print ISSN	0960-9822
Publisher	Cell Press
Peer Reviewed	Peer Reviewed
Volume	30
Issue	8
Pages	1423.e3-1423.e3
DOI	https://doi.org/10.1016/j.cub.2020.01.089

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http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).