Skip to main content

Research Repository

Advanced Search

Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification

Meksawangwong, Sureemas; Gohil, Bhavini; Punyain, Wikorn; Pal, Robert; Kielar, Filip

Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification Thumbnail


Authors

Sureemas Meksawangwong

Bhavini Gohil

Wikorn Punyain

Filip Kielar



Abstract

Herein we report the synthesis and investigation of two novel tris-cyclometalated iridium complexes derived from [Ir(ppy)3] and bearing an aminoalkyl substituent on one of the 2-phenylpyridine ligands. These complexes differ in the number of the alkyl substituents of the aminoalkyl group. Specifically, the complexes reported herein contain one (1) and two (2) 2-hydroxy ethyl groups on the nitrogen atom. Both complexes retain the good photophysical properties reported for earlier versions of this group of tris-cyclometalated iridium complexes. However, the differences in the substitution results in changes in the responsive photoluminescence behavior in aqueous solutions. Live cell microscopy experiments revealed that complexes can localize in NIH-3T3 cells. Finally, it has been observed that the complex containing two 2-hydroxy ethyl groups is less cytotoxic than the it’s mono-substituted counterpart

Citation

Meksawangwong, S., Gohil, B., Punyain, W., Pal, R., & Kielar, F. (2020). Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification. Inorganica Chimica Acta, 508, Article 119609. https://doi.org/10.1016/j.ica.2020.119609

Journal Article Type Article
Acceptance Date Mar 19, 2020
Online Publication Date Mar 20, 2020
Publication Date Aug 1, 2020
Deposit Date Mar 22, 2020
Publicly Available Date Mar 28, 2024
Journal Inorganica Chimica Acta
Print ISSN 0020-1693
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 508
Article Number 119609
DOI https://doi.org/10.1016/j.ica.2020.119609

Files





You might also like



Downloadable Citations