Cookies

We use cookies to ensure that we give you the best experience on our website. By continuing to browse this repository, you give consent for essential cookies to be used. You can read more about our Privacy and Cookie Policy.


Durham Research Online
You are in:

Characterisation of the interactions of aromatic amino acids with diacetyl phosphatidylcholine.

Sanderson, J. M. and Whelan, E. J. (2004) 'Characterisation of the interactions of aromatic amino acids with diacetyl phosphatidylcholine.', Physical chemistry chemical physics., 6 (5). pp. 1012-1017.

Abstract

A simple bimolecular system for characterising the interactions of amino acids with diacyl-3-phosphatidylcholines has been developed. The system contains two components: an N-acetyl amino acid N'-alkyl amide and diacetyl-3-sn-phosphatidylcholine (DAPC). Interactions between a series of aromatic amino acids and DAPC have been characterised by H-1 NMR techniques. Of the amino acids examined, tryptophan and tyrosine were shown to have particularly favourable interactions with the DAPC choline headgroup. Our observations are consistent with the previously reported tendency for these amino acids to occur preferentially at the lipid-water interface. Using data from ROESY experiments and complexation-induced chemical shift changes, we have been able to generate molecular models for the tryptophan-DAPC adduct that are consistent with the observed results. The adduct is characterised by amide carbonyl-cation interactions, hydrogen bonding and cation-pi interactions.

Item Type:Article
Full text:Full text not available from this repository.
Publisher Web site:http://dx.doi.org/10.1039/b312184d
Record Created:25 Apr 2007
Last Modified:03 Jan 2012 15:07

Social bookmarking: del.icio.usConnoteaBibSonomyCiteULikeFacebookTwitterExport: EndNote, Zotero | BibTex
Usage statisticsLook up in GoogleScholar | Find in a UK Library