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Elemental fluorine : part 18 : selective direct fluorination of 1,3-ketoesters and 1,3-diketones using gas/liquid microreactor technology.

Chambers, R. D. and Fox, M. A. and Sandford, G. (2005) 'Elemental fluorine : part 18 : selective direct fluorination of 1,3-ketoesters and 1,3-diketones using gas/liquid microreactor technology.', Lab on a chip., 5 (10). pp. 1132-1139.

Abstract

1,3-Ketoesters and 1,3-diketones react with fluorine gas, using Durham multichannel modular microreactor technology, on a preparatively useful scale. High conversions and yields of monofluorinated products were obtained. A consideration of the mechanism of fluorination of dicarbonyl systems provides a rationale of the scope and limitations of the use of microreactor technology for such direct fluorination processes. We conclude that it is especially appropriate for the fluorination of diketones and ketoesters that exist mainly in the enol form at equilibrium and/or undergo rapid keto - enol interconversion. A one-stage route to fluoroketones from ketoesters was achieved by allowing the crude product mixture obtained from the fluorination of the ketoesters to stand for a period of time before reaction work-up.

Item Type:Article
Full text:Full text not available from this repository.
Publisher Web site:http://dx.doi.org/10.1039/b504675k
Record Created:26 Apr 2007
Last Modified:08 Apr 2009 16:30

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