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Elemental fluorine : part 19 : electrophilic fluorination of hexyl derivatives bearing electron withdrawing groups.

Chambers, R. D. and Parsons, M. and Sandford, G. and Thomas, E. and Trmcic, J. and Moilliet, J. S. (2006) 'Elemental fluorine : part 19 : electrophilic fluorination of hexyl derivatives bearing electron withdrawing groups.', Tetrahedron., 62 (30). pp. 7162-7167.

Abstract

Reaction of a series of model hexyl derivatives of the form C6H13–X (X=Cl, Br, I, CO2Me, COMe, CHO) with both elemental fluorine and Selectfluor™ was studied in order to assess the impact of electron withdrawing functional groups upon fluorination of an alkyl chain. Fluorination generally occurs at secondary sites, with a slight preference for those that are furthest removed from the electron withdrawing group, consistent with an electrophilic substitution process, although mixtures of fluorinated products are obtained in most cases.

Item Type:Article
Full text:Full text not available from this repository.
Publisher Web site:http://dx.doi.org/10.1016/j.tet.2006.03.113
Record Created:26 Apr 2007
Last Modified:08 Apr 2009 16:30

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