R.S. Dickins
A new chiral lanthanide NMR probe for the determination of the enantiomeric purity of α-hydroxy acids and the absolute configuration of α-amino acids in water
Dickins, R.S.; Badari, A.
Authors
A. Badari
Abstract
A water-soluble, enantiopure lanthanide complex, SSS-[Ln(.)L(3)], has been assessed as an effective chiral derivatising agent for the determination of the enantiomeric purity of a-hydroxy acids in aqueous solution. The complex displays superior chemical shift non-equivalence (Delta Delta delta similar to 2-11 ppm) for the diastereomeric resonances of interest compared to lanthanide shift reagents reported in the literature (Delta Delta delta < 0.1 ppm, typically). H-1 NMR studies have also revealed that SSS-[Ln(.)L(3)] can be used to determine the absolute configuration of a-amino acids at physiological pH, in water. The ability of SSS-[Ln(.)L(3)] to signal anion binding and, in particular, to distinguish between diastereomers through optical techniques such as lanthanide luminescence and circular dichroism has also been assessed.
Citation
Dickins, R., & Badari, A. (2006). A new chiral lanthanide NMR probe for the determination of the enantiomeric purity of α-hydroxy acids and the absolute configuration of α-amino acids in water. Dalton Transactions, 3088-3096. https://doi.org/10.1039/b513814k
Journal Article Type | Article |
---|---|
Publication Date | Mar 13, 2006 |
Deposit Date | May 3, 2007 |
Journal | Dalton Transactions |
Print ISSN | 1477-9226 |
Electronic ISSN | 1477-9234 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Issue | 25 |
Pages | 3088-3096 |
DOI | https://doi.org/10.1039/b513814k |
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