SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants

Roy, Dipan; Sadanandom, Ari

doi:10.1007/s00018-020-03723-4

SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants

Roy, Dipan; Sadanandom, Ari

Authors

Dipan Roy

Professor Ari Sadanandom ari.sadanandom@durham.ac.uk
Professor

Abstract

Across all species, transcription factors (TFs) are the most frequent targets of SUMOylation. The effect of SUMO conjugation on the functions of transcription factors has been extensively studied in animal systems, with over 200 transcription factors being documented to be modulated by SUMOylation. This has resulted in the establishment of a number of paradigms that seek to explain the mechanisms by which SUMO regulates transcription factor functions. For instance, SUMO has been shown to modulate TF DNA binding activity; regulate both localization as well as the abundance of TFs and also influence the association of TFs with chromatin. With transcription factors being implicated as master regulators of the cellular signalling pathways that maintain phenotypic plasticity in all organisms, in this review, we will discuss how SUMO mediated regulation of transcription factor activity facilitates molecular pathways to mount an appropriate and coherent biological response to environmental cues.

Citation

Roy, D., & Sadanandom, A. (2021). SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants. Cellular and Molecular Life Sciences, 78(6), 2641-2664. https://doi.org/10.1007/s00018-020-03723-4

Journal Article Type	Article
Acceptance Date	Nov 25, 2020
Online Publication Date	Jan 16, 2021
Publication Date	2021-03
Deposit Date	Apr 14, 2021
Publicly Available Date	Apr 14, 2021
Journal	Cellular and Molecular Life Sciences
Print ISSN	1420-682X
Electronic ISSN	1420-9071
Publisher	Springer
Peer Reviewed	Peer Reviewed
Volume	78
Issue	6
Pages	2641-2664
DOI	https://doi.org/10.1007/s00018-020-03723-4

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