Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties

Gimenez, Diana; Phelan, Aoife; Murphy, Cormac D.; Cobb, Steven L.

doi:10.1021/acs.orglett.1c01387

Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties

Gimenez, Diana; Phelan, Aoife; Murphy, Cormac D.; Cobb, Steven L.

Authors

Diana Gimenez

Aoife Phelan

Cormac D. Murphy

Professor Steven Cobb s.l.cobb@durham.ac.uk
Professor

Abstract

Fengycins are cyclic lipo-depsipeptides produced by Bacillus spp. that display potent antifungal properties but are chemically unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the synthesis of fengycin A analogues that display enhanced antifungal properties and chemical stability under both basic and acidic conditions. The analogues prepared also demonstrate that the fengycin core structure can be modified and simplified without the loss of antifungal activity.

Citation

Gimenez, D., Phelan, A., Murphy, C. D., & Cobb, S. L. (2021). Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties. Organic Letters, 23(12), 4672-4676. https://doi.org/10.1021/acs.orglett.1c01387

Journal Article Type	Article
Online Publication Date	Jun 2, 2021
Publication Date	2021-06
Deposit Date	Jun 24, 2021
Publicly Available Date	Jun 24, 2021
Journal	Organic Letters
Print ISSN	1523-7060
Electronic ISSN	1523-7052
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	23
Issue	12
Pages	4672-4676
DOI	https://doi.org/10.1021/acs.orglett.1c01387