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Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review

Raghunath, A.; Hungin, A.P.S.; Wooff, D.; Childs, S.

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Authors

A. Raghunath

A.P.S. Hungin

D. Wooff

S. Childs



Contributors

Richard Smith
Editor

Abstract

Objectives: To ascertain the prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease and its association with the disease. Design: Systematic review of studies reporting the prevalence of H pylori in patients with and without gastro-oesophageal reflux disease. Data sources: Four electronic databases, searched to November 2001, experts, pharmaceutical companies, and journals. Main outcome measure: Odds ratio for prevalence of H pylori in patients with gastro-oesophageal reflux disease. Results: 20 studies were included. The pooled estimate of the odds ratio for prevalence of H pylori was 0.60 (95% confidence interval 0.47 to 0.78), indicating a lower prevalence in patients with gastro-oesophageal reflux disease. Substantial heterogeneity was observed between studies. Location seemed to be an important factor, with a much lower prevalence of H pylori in patients with gastro-oesophageal reflux disease in studies from the Far East, despite a higher overall prevalence of infection than western Europe and North America. Year of study was not a source of heterogeneity. Conclusion: The prevalence of H pylori infection was significantly lower in patients with than without gastro-oesophageal reflux, with geographical location being a strong contributor to the heterogeneity between studies. Patients from the Far East with reflux disease had a lower prevalence of H pylori infection than patients from western Europe and North America, despite a higher prevalence in the general population.

Citation

Raghunath, A., Hungin, A., Wooff, D., & Childs, S. (2003). Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review. eBMJ (London), 326(7392), 737-739. https://doi.org/10.1136/bmj.326.7392.737

Journal Article Type Article
Publication Date Apr 1, 2003
Deposit Date May 9, 2007
Publicly Available Date Mar 29, 2024
Journal British medical journal (Clinical research edition)
Electronic ISSN 1468-5833
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 326
Issue 7392
Pages 737-739
DOI https://doi.org/10.1136/bmj.326.7392.737

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