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Rewritable DNA microarrays

Schofield, W.C.E.; McGettrick, J.; Bradley, T.J.; Badyal, J.P.S.; Przyborski, S.

Authors

W.C.E. Schofield

J. McGettrick

T.J. Bradley

S. Przyborski



Abstract

Thiol-terminated single-stranded deoxyribonucleic acids (ssDNA) can be immobilized onto pulsed plasma deposited poly(allylmercaptan) surfaces via disulfide bridge chemistry and are found to readily undergo nucleic acid hybridization. Unlike other methods for oligonucleotide attachment to solid surfaces, this approach is shown to be independent of substrate material or geometry, and amenable to highly efficient rewriting.

Citation

Schofield, W., McGettrick, J., Bradley, T., Badyal, J., & Przyborski, S. (2006). Rewritable DNA microarrays. Journal of the American Chemical Society, 128(7), 2280-2285. https://doi.org/10.1021/ja056367r

Journal Article Type Article
Publication Date Jan 1, 2006
Deposit Date May 10, 2007
Journal Journal of the American Chemical Society
Print ISSN 0002-7863
Electronic ISSN 1520-5126
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 128
Issue 7
Pages 2280-2285
DOI https://doi.org/10.1021/ja056367r

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