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Rewritable DNA microarrays.

Schofield, W. C. E. and McGettrick, J. and Bradley, T. J. and Badyal, J. P. S. and Przyborski, S. (2006) 'Rewritable DNA microarrays.', Journal of the American Chemical Society., 128 (7). pp. 2280-2285.


Thiol-terminated single-stranded deoxyribonucleic acids (ssDNA) can be immobilized onto pulsed plasma deposited poly(allylmercaptan) surfaces via disulfide bridge chemistry and are found to readily undergo nucleic acid hybridization. Unlike other methods for oligonucleotide attachment to solid surfaces, this approach is shown to be independent of substrate material or geometry, and amenable to highly efficient rewriting.

Item Type:Article
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Record Created:10 May 2007
Last Modified:08 Apr 2009 16:31

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