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Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds from 4-phenylsulfonyl tetrafluoropyridine

Baron, A.; Sandford, G.; Slater, R.; Yufit, D.S.; Howard, J.A.K.; Vong, A.

Authors

A. Baron

G. Sandford

R. Slater

D.S. Yufit

J.A.K. Howard

A. Vong



Abstract

Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds can be synthesized by sequential reaction of pentafluoropyridine with sodium phenylsulfinate and an appropriate diamine. The polyfunctionality possessed by the difluorinated tetrahydropyrido[2,3-b]pyrazine scaffolds was demonstrated in selected model reactions with nucleophiles to give access to various polysubstituted [6,6]-ring fused systems.

Citation

Baron, A., Sandford, G., Slater, R., Yufit, D., Howard, J., & Vong, A. (2005). Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds from 4-phenylsulfonyl tetrafluoropyridine. Journal of Organic Chemistry, 70(23), 9377-9381. https://doi.org/10.1021/jo051453v

Journal Article Type Article
Publication Date Oct 1, 2005
Deposit Date May 11, 2007
Journal Journal of Organic Chemistry
Print ISSN 0022-3263
Electronic ISSN 1520-6904
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 70
Issue 23
Pages 9377-9381
DOI https://doi.org/10.1021/jo051453v