Skip to main content

Research Repository

Advanced Search

Crystal Habit Modification of Metronidazole by Supramolecular Gels with Complementary Functionality

Jayabhavan, Sreejith Sudhakaran; Steed, Jonathan W.; Damodaran, Krishna K.

Crystal Habit Modification of Metronidazole by Supramolecular Gels with Complementary Functionality Thumbnail


Authors

Sreejith Sudhakaran Jayabhavan

Krishna K. Damodaran



Abstract

A series of bis(urea) compounds with complementary functional groups similar to the pharmaceutical drug metronidazole and a structural isomer isometronidazole have been synthesized. The gelation properties of these compounds were studied in various solvent/solvent mixtures. The mechanical strength of the isomeric gelators was compared using rheology, and the morphologies of the xerogels were analyzed by scanning electron microscopy. These gels were used as media for metronidazole crystallization resulting in a marked habit modification of the metronidazole crystals in the drug-mimicking gels. However, crystallization in the nonmimetic isomeric gel resulted in morphologies similar to the solution state. These results indicate that the drug-mimetic gels interact with the surface of the drug crystal giving rise to new morphologies.

Citation

Jayabhavan, S. S., Steed, J. W., & Damodaran, K. K. (2021). Crystal Habit Modification of Metronidazole by Supramolecular Gels with Complementary Functionality. Crystal Growth and Design, 21(9), 5383-5393. https://doi.org/10.1021/acs.cgd.1c00659

Journal Article Type Article
Acceptance Date Jul 15, 2021
Online Publication Date Jul 30, 2021
Publication Date Sep 1, 2021
Deposit Date Oct 28, 2021
Publicly Available Date Jul 30, 2022
Journal Crystal Growth & Design
Print ISSN 1528-7483
Electronic ISSN 1528-7505
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 21
Issue 9
Pages 5383-5393
DOI https://doi.org/10.1021/acs.cgd.1c00659

Files

Accepted Journal Article (860 Kb)
PDF

Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.1c00659





You might also like



Downloadable Citations