Protein metalation in biology

Foster, Andrew W.; Young, Tessa R.; Chivers, Peter T.; Robinson, Nigel J.

doi:10.1016/j.cbpa.2021.102095

Protein metalation in biology

Foster, Andrew W.; Young, Tessa R.; Chivers, Peter T.; Robinson, Nigel J.

Authors

Andrew W. Foster

Dr Tessa Young tessa.r.young@durham.ac.uk
Assistant Professor

Dr Peter Chivers peter.chivers@durham.ac.uk
Associate Professor

Professor Nigel Robinson nigel.robinson@durham.ac.uk
Professor

Abstract

Inorganic metals supplement the chemical repertoire of organic molecules, especially proteins. This requires the correct metals to associate with proteins at metalation. Protein mismetalation typically occurs when excesses of unbound metals compete for a binding site ex vivo. However, in biology, excesses of metal-binding sites typically compete for limiting amounts of exchangeable metals. Here, we summarise mechanisms of metal homeostasis that sustain optimal metal availabilities in biology. We describe recent progress to understand metalation by comparing the strength of metal binding to a protein versus the strength of binding to competing sites inside cells.

Citation

Foster, A. W., Young, T. R., Chivers, P. T., & Robinson, N. J. (2022). Protein metalation in biology. Current Opinion in Chemical Biology, 66, Article 102095. https://doi.org/10.1016/j.cbpa.2021.102095

Journal Article Type	Article
Online Publication Date	Nov 8, 2021
Publication Date	2022-02
Deposit Date	Nov 19, 2021
Publicly Available Date	Dec 7, 2021
Journal	Current Opinion in Chemical Biology
Print ISSN	1367-5931
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	66
Article Number	102095
DOI	https://doi.org/10.1016/j.cbpa.2021.102095

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http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2021 The Authors. Published by Elsevier Ltd. This is an
open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)