Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro

Costello, Lydia; Dicolandrea, Teresa; Tasseff, Ryan; Isfort, Robert; Bascom, Charlie; von Zglinicki, Thomas; Przyborski, Stefan

doi:10.1111/acel.13550

Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro

Costello, Lydia; Dicolandrea, Teresa; Tasseff, Ryan; Isfort, Robert; Bascom, Charlie; von Zglinicki, Thomas; Przyborski, Stefan

Authors

Lydia Costello

Teresa Dicolandrea

Ryan Tasseff

Robert Isfort

Charlie Bascom

Thomas von Zglinicki

Professor Stefan Przyborski stefan.przyborski@durham.ac.uk
Executive Dean

Abstract

Human skin ageing is a complex and heterogeneous process, which is influenced by genetically determined intrinsic factors and accelerated by cumulative exposure to extrinsic stressors. In the current world ageing demographic, there is a requirement for a bioengineered ageing skin model, to further the understanding of the intricate molecular mechanisms of skin ageing, and provide a distinct and biologically relevant platform for testing actives and formulations. There have been many recent advances in the development of skin models that recapitulate aspects of the ageing phenotype in vitro. This review encompasses the features of skin ageing, the molecular mechanisms that drive the ageing phenotype, and tissue engineering strategies that have been utilised to bioengineer ageing skin in vitro.

Citation

Costello, L., Dicolandrea, T., Tasseff, R., Isfort, R., Bascom, C., von Zglinicki, T., & Przyborski, S. (2022). Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro. Aging Cell, 21(2), Article e13550. https://doi.org/10.1111/acel.13550

Journal Article Type	Article
Acceptance Date	Dec 29, 2021
Online Publication Date	Jan 17, 2022
Publication Date	Feb 14, 2022
Deposit Date	Jan 18, 2022
Publicly Available Date	Jan 18, 2022
Journal	Aging Cell
Print ISSN	1474-9718
Electronic ISSN	1474-9726
Publisher	Anatomical Society of Great Britain and Ireland
Peer Reviewed	Peer Reviewed
Volume	21
Issue	2
Article Number	e13550
DOI	https://doi.org/10.1111/acel.13550

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Early View © 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.

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