D Salina
Cytoplasmic dynein as a facilitator of nuclear envelope breakdown
Salina, D; Bodoor, K; Eckley, DM; Schroer, TA; Rattner, JB; Burke, B
Authors
K Bodoor
DM Eckley
TA Schroer
JB Rattner
B Burke
Abstract
During prophase in higher cells, centrosomes localize to deep invaginations in the nuclear envelope in a microtubule-dependent process. Loss of nuclear membranes in prometaphase commences in regions of the nuclear envelope that lie outside of these invaginations. Dynein and dynactin complex components concentrate on the nuclear envelope prior to any changes in nuclear envelope organization. These observations suggest a model in which dynein facilitates nuclear envelope breakdown by pulling nuclear membranes and associated proteins poleward along astral microtubules leading to nuclear membrane detachment. Support for this model is provided by the finding that interference with dynein function drastically alters nuclear membrane dynamics in prophase and prometaphase.
Citation
Salina, D., Bodoor, K., Eckley, D., Schroer, T., Rattner, J., & Burke, B. (2002). Cytoplasmic dynein as a facilitator of nuclear envelope breakdown. Cell, 108(1), 97-107. https://doi.org/10.1016/s0092-8674%2801%2900628-6
Journal Article Type | Article |
---|---|
Publication Date | Jan 1, 2002 |
Deposit Date | May 16, 2007 |
Journal | Cell |
Print ISSN | 0092-8674 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 108 |
Issue | 1 |
Pages | 97-107 |
DOI | https://doi.org/10.1016/s0092-8674%2801%2900628-6 |
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