Skip to main content

Research Repository

Advanced Search

Cytoplasmic dynein as a facilitator of nuclear envelope breakdown

Salina, D; Bodoor, K; Eckley, DM; Schroer, TA; Rattner, JB; Burke, B

Authors

D Salina

K Bodoor

DM Eckley

TA Schroer

JB Rattner

B Burke



Abstract

During prophase in higher cells, centrosomes localize to deep invaginations in the nuclear envelope in a microtubule-dependent process. Loss of nuclear membranes in prometaphase commences in regions of the nuclear envelope that lie outside of these invaginations. Dynein and dynactin complex components concentrate on the nuclear envelope prior to any changes in nuclear envelope organization. These observations suggest a model in which dynein facilitates nuclear envelope breakdown by pulling nuclear membranes and associated proteins poleward along astral microtubules leading to nuclear membrane detachment. Support for this model is provided by the finding that interference with dynein function drastically alters nuclear membrane dynamics in prophase and prometaphase.

Citation

Salina, D., Bodoor, K., Eckley, D., Schroer, T., Rattner, J., & Burke, B. (2002). Cytoplasmic dynein as a facilitator of nuclear envelope breakdown. Cell, 108(1), 97-107. https://doi.org/10.1016/s0092-8674%2801%2900628-6

Journal Article Type Article
Publication Date Jan 1, 2002
Deposit Date May 16, 2007
Journal Cell
Print ISSN 0092-8674
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 108
Issue 1
Pages 97-107
DOI https://doi.org/10.1016/s0092-8674%2801%2900628-6