Lydia Kitchen lydia.kitchen@durham.ac.uk
Lab Technician
Rationale for 1068 nm Photobiomodulation Therapy (PBMT) as a Novel, Non-Invasive Treatment for COVID-19 and Other Coronaviruses: Roles of NO and Hsp70
Kitchen, Lydia C.; Berman, Marvin; Halper, James; Chazot, Paul
Authors
Marvin Berman
James Halper
Professor Paul Chazot paul.chazot@durham.ac.uk
Professor
Abstract
Researchers from across the world are seeking to develop effective treatments for the ongoing coronavirus disease 2019 (COVID-19) outbreak, which arose as a major public health issue in 2019, and was declared a pandemic in early 2020. The pro-inflammatory cytokine storm, acute respiratory distress syndrome (ARDS), multiple-organ failure, neurological problems, and thrombosis have all been linked to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) fatalities. The purpose of this review is to explore the rationale for using photobiomodulation therapy (PBMT) of the particular wavelength 1068 nm as a therapy for COVID-19, investigating the cellular and molecular mechanisms involved. Our findings illustrate the efficacy of PBMT 1068 nm for cytoprotection, nitric oxide (NO) release, inflammation changes, improved blood flow, and the regulation of heat shock proteins (Hsp70). We propose, therefore, that PBMT 1068 is a potentially effective and innovative approach for avoiding severe and critical illness in COVID-19 patients, although further clinical evidence is required.
Citation
Kitchen, L. C., Berman, M., Halper, J., & Chazot, P. (2022). Rationale for 1068 nm Photobiomodulation Therapy (PBMT) as a Novel, Non-Invasive Treatment for COVID-19 and Other Coronaviruses: Roles of NO and Hsp70. International Journal of Molecular Sciences, 23(9), Article 5221. https://doi.org/10.3390/ijms23095221
Journal Article Type | Article |
---|---|
Acceptance Date | May 4, 2022 |
Online Publication Date | May 7, 2022 |
Publication Date | May 1, 2022 |
Deposit Date | May 9, 2022 |
Publicly Available Date | Mar 29, 2024 |
Journal | International Journal of Molecular Sciences |
Print ISSN | 1661-6596 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 23 |
Issue | 9 |
Article Number | 5221 |
DOI | https://doi.org/10.3390/ijms23095221 |
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Copyright Statement
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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