Membrane contact sites and cytoskeleton-membrane interactions in autophagy

Duckney, Patrick J.; Wang, Pengwei; Hussey, Patrick J.

doi:10.1002/1873-3468.14414

Membrane contact sites and cytoskeleton-membrane interactions in autophagy

Duckney, Patrick J.; Wang, Pengwei; Hussey, Patrick J.

Authors

Dr Patrick Duckney patrick.duckney@durham.ac.uk
Post Doctoral Research Associate

Pengwei Wang

Professor Patrick Hussey p.j.hussey@durham.ac.uk
Professor

Abstract

In Eukaryotes, organelle interactions occur at specialised contact sites between organelle membranes. Contact sites are regulated by specialised tethering proteins, which bring organelle membranes into close proximity, and facilitate functional crosstalk between compartments. Whilst contact site proteins are well characterised in mammals and yeast, the regulators of plant contact site formation are only now beginning to emerge. Having unique subcellular structures, plants must also utilise unique mechanisms of organelle interaction to regulate plant-specific functions. The recently characterised NETWORKED proteins are the first dedicated family of plant-specific contact site proteins. Research into the NET proteins and their interacting partners continues to uncover plantspecific mechanisms of organelle interaction and the importance of these organelle contacts to plant life. Moreover, it is becoming increasingly apparent that organelle interactions are fundamental to autophagy in plants. Here, we will present recent developments in our understanding of the mechanisms of plant organelle interactions, their functions, and emerging roles in autophagy.

Citation

Duckney, P. J., Wang, P., & Hussey, P. J. (2022). Membrane contact sites and cytoskeleton-membrane interactions in autophagy. FEBS Letters, 596(17), 2093-2103. https://doi.org/10.1002/1873-3468.14414

Journal Article Type	Article
Acceptance Date	May 12, 2022
Online Publication Date	Jun 1, 2022
Publication Date	2022-09
Deposit Date	Jul 18, 2022
Publicly Available Date	Feb 7, 2023
Journal	FEBS Letters
Print ISSN	0014-5793
Publisher	Federation of European Biochemical Societies
Peer Reviewed	Peer Reviewed
Volume	596
Issue	17
Pages	2093-2103
DOI	https://doi.org/10.1002/1873-3468.14414

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© 2022 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

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