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Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety

Tataridas-Pallas, Nikolaos; Thompson, Maximillian A.; Howard, Alexander; Brown, Ian; Ezcurra, Marina; Wu, Ziyun; Silva, Isabel Goncalves; Saunter, Christopher D.; Kuerten, Timo; Weinkove, David; Blackwell, T. Keith; Tullet, Jennifer M.A.

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Authors

Nikolaos Tataridas-Pallas

Maximillian A. Thompson

Alexander Howard

Ian Brown

Marina Ezcurra

Ziyun Wu

Isabel Goncalves Silva

Christopher D. Saunter

Timo Kuerten

T. Keith Blackwell

Jennifer M.A. Tullet



Abstract

The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones to control food-related behaviour and physiology. Here we identify a new component of this system, SKN-1B which acts as a central food-responsive node, ultimately controlling satiety and metabolic homeostasis. SKN-1B, an ortholog of mammalian NF-E2 related transcription factors (Nrfs), has previously been implicated with metabolism, respiration and the increased lifespan incurred by dietary restriction. Here we show that SKN-1B acts in two hypothalamus-like ASI neurons to sense food, communicate nutritional status to the organism, and control satiety and exploratory behaviours. This is achieved by SKN-1B modulating endocrine signalling pathways (IIS and TGF-β), and by promoting a robust mitochondrial network. Our data suggest a food-sensing and satiety role for mammalian Nrf proteins.

Citation

Tataridas-Pallas, N., Thompson, M. A., Howard, A., Brown, I., Ezcurra, M., Wu, Z., …Tullet, J. M. (2021). Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety. PLoS Genetics, 17(3), Article e1009358. https://doi.org/10.1371/journal.pgen.1009358

Journal Article Type Article
Acceptance Date Jan 17, 2021
Online Publication Date Mar 4, 2021
Publication Date 2021
Deposit Date Oct 23, 2022
Publicly Available Date Oct 24, 2022
Journal PLOS Genetics
Print ISSN 1553-7390
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 17
Issue 3
Article Number e1009358
DOI https://doi.org/10.1371/journal.pgen.1009358

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2021 Tataridas-Pallas et al. This is an
open access article distributed under the terms of
the Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.





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