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Structural remodelling of lungs in chronic heart failure.

Kingsbury, M. P. and Huang, W. and Donnelly, J. L. and Jackson, E. and Needham, E. and Turner, M. A. and Sheridan, D. J. (2003) 'Structural remodelling of lungs in chronic heart failure.', Basic research in cardiology., 98 (5). pp. 295-303.

Abstract

In order to determine whether morphological changes could account for a previously reported reduction in pulmonary capillary ltration in heart failure, we studied pulmonary morphology in lungs from a guineapig chronic heart failure model. Heart failure was induced by banding the ascending aorta with sham operated animals serving as controls; all animals were studied at 158 ± 6 days post-operation. Following banding, a reduction in aortic ow, increased peripheral vascular resistance and raised left ventricular end diastolic, left atrial and right ventricular pressures together with increased right ventricle to body weight ratio (all p < 0.05) are indicative of established pulmonary hypertension and heart failure. This was associated with an increase in pulmonary septal volume fraction (38.1 ± 3.1% vs 24.6 ± 2.3 %, p < 0.01) and reticulin fibre density. There was also evidence of siderophage infiltration and examination of pulmonary ultra structure revealed a signicantly thicker alveolar-capillary barrier in heart failure (1278 ±76 vs 638 ± 32 nm, p < 0.001), thickening of both the alveolar (89%, p < 0.01) and capillary (69%, p < 0.05) basal laminae with pericyte and collagen inltration of the alveolar-capillary barrier. We hypothesise that these pulmonary adaptations provide protection from oedema formation, but whilst initially protective, are also likely to confer major long-term disadvantages in chronic heart failure.

Item Type:Article
Additional Information:
Keywords:Heart failure, Pulmonary circulation, Membrane permeability remodelling, Extracellular matrix.
Full text:Full text not available from this repository.
Publisher Web site:http://dx.doi.org/10.1007/s00395-003-0419-6
Record Created:12 Feb 2009
Last Modified:08 Apr 2009 16:32

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