J.G. Reilly
Thioridazine and sudden unexplained death in psychiatric patients
Reilly, J.G.; Ayis, S.A.; Ferrier, I.N.; Jones, S.J.; Thomas, S.H.L.
Authors
S.A. Ayis
I.N. Ferrier
S.J. Jones
S.H.L. Thomas
Abstract
Background Sudden death has been linked to antipsychotic therapy, but the relative risk associated with specific drugs is unknown. Aims To assess the risk of sudden unexplained death associated with antipsychotic drug therapy and its relation to drug dose and individual agents. Method A case—control study of psychiatric in-patients dying suddenly in five hospitals in the north-east of England and surviving controls matched for age, gender and mental disorder. Logistic regression analysis was used to identify significant risk factors, and odds ratios were calculated. Results Sixty-nine case—control clusters were identified. Probable sudden unexplained death was significantly associated with hypertension, ischaemic heart disease and current treatment with thioridazine (adjusted odds ratio=5.3, 95% CI 1.7-16.2, P=0.004). There was no significant association with other individual antipsychotic drugs. Conclusions Thioridazine alone was associated with sudden unexplained death, the likely mechanism being drug induced arrythmia.
Citation
Reilly, J., Ayis, S., Ferrier, I., Jones, S., & Thomas, S. (2002). Thioridazine and sudden unexplained death in psychiatric patients. British Journal of Psychiatry, 180(6), 515-522. https://doi.org/10.1192/bjp.180.6.515
Journal Article Type | Article |
---|---|
Publication Date | Jun 1, 2002 |
Deposit Date | May 30, 2007 |
Journal | British Journal of Psychiatry |
Print ISSN | 0007-1250 |
Electronic ISSN | 1472-1465 |
Publisher | Royal College of Psychiatrists |
Peer Reviewed | Peer Reviewed |
Volume | 180 |
Issue | 6 |
Pages | 515-522 |
DOI | https://doi.org/10.1192/bjp.180.6.515 |
Publisher URL | http://bjp.rcpsych.org/cgi/content/abstract/180/6/515 |
You might also like
Personality disorder prevalence in psychiatric outpatients: A systematic literature review
(2014)
Journal Article
Renal Failure in Lithium-Treated Bipolar Disorder: A Retrospective Cohort Study
(2014)
Journal Article
Downloadable Citations
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search