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Chemically amplified ¹⁹F-¹H nuclear Overhauser effects

Kuprov, I.; Hore, P.J.

Authors

I. Kuprov

P.J. Hore



Abstract

Chemically induced dynamic nuclear polarisation (CIDNP) is explored as a source of nuclear hyperpolarisation in heteronuclear Overhauser effect experiments. A photochemical reaction proceeding through a radical pair intermediate is used to enhance 19F nuclear magnetisation in 3-fluorotyrosine by more than an order of magnitude with a corresponding increase in the amplitudes of 19F–1H cross-relaxation and cross-correlation effects. The reactions employed are cyclic and leave the sample chemically unchanged. The potential for enhancing the sensitivity of heteronuclear NOEs in 19F-labelled proteins is discussed.

Citation

Kuprov, I., & Hore, P. (2004). Chemically amplified ¹⁹F-¹H nuclear Overhauser effects. Journal of Magnetic Resonance, 168(1), 1-7. https://doi.org/10.1016/j.jmr.2004.01.011

Journal Article Type Article
Publication Date May 1, 2004
Deposit Date Jan 16, 2008
Journal Journal of Magnetic Resonance
Print ISSN 1090-7807
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 168
Issue 1
Pages 1-7
DOI https://doi.org/10.1016/j.jmr.2004.01.011
Keywords NMR, CIDNP, NOE, Fluorine, Amino acid.