I. Kuprov
Chemically amplified ¹⁹F-¹H nuclear Overhauser effects
Kuprov, I.; Hore, P.J.
Authors
P.J. Hore
Abstract
Chemically induced dynamic nuclear polarisation (CIDNP) is explored as a source of nuclear hyperpolarisation in heteronuclear Overhauser effect experiments. A photochemical reaction proceeding through a radical pair intermediate is used to enhance 19F nuclear magnetisation in 3-fluorotyrosine by more than an order of magnitude with a corresponding increase in the amplitudes of 19F–1H cross-relaxation and cross-correlation effects. The reactions employed are cyclic and leave the sample chemically unchanged. The potential for enhancing the sensitivity of heteronuclear NOEs in 19F-labelled proteins is discussed.
Citation
Kuprov, I., & Hore, P. (2004). Chemically amplified ¹⁹F-¹H nuclear Overhauser effects. Journal of Magnetic Resonance, 168(1), 1-7. https://doi.org/10.1016/j.jmr.2004.01.011
Journal Article Type | Article |
---|---|
Publication Date | May 1, 2004 |
Deposit Date | Jan 16, 2008 |
Journal | Journal of Magnetic Resonance |
Print ISSN | 1090-7807 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 168 |
Issue | 1 |
Pages | 1-7 |
DOI | https://doi.org/10.1016/j.jmr.2004.01.011 |
Keywords | NMR, CIDNP, NOE, Fluorine, Amino acid. |
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