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Chemically amplified 19F-1H nuclear Overhauser effects.

Kuprov, I. and Hore, P. J. (2004) 'Chemically amplified 19F-1H nuclear Overhauser effects.', Journal of magnetic resonance., 168 (1). pp. 1-7.


Chemically induced dynamic nuclear polarisation (CIDNP) is explored as a source of nuclear hyperpolarisation in heteronuclear Overhauser effect experiments. A photochemical reaction proceeding through a radical pair intermediate is used to enhance 19F nuclear magnetisation in 3-fluorotyrosine by more than an order of magnitude with a corresponding increase in the amplitudes of 19F–1H cross-relaxation and cross-correlation effects. The reactions employed are cyclic and leave the sample chemically unchanged. The potential for enhancing the sensitivity of heteronuclear NOEs in 19F-labelled proteins is discussed.

Item Type:Article
Keywords:NMR, CIDNP, NOE, Fluorine, Amino acid.
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Record Created:16 Jan 2008
Last Modified:14 Jun 2016 13:41

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