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Chemically amplified 19F-1H nuclear Overhauser effects

Kuprov, I. and Hore, P. J. (2004) 'Chemically amplified 19F-1H nuclear Overhauser effects.', Journal of magnetic resonance., 168 (1). pp. 1-7.

Abstract

Chemically induced dynamic nuclear polarisation (CIDNP) is explored as a source of nuclear hyperpolarisation in heteronuclear Overhauser effect experiments. A photochemical reaction proceeding through a radical pair intermediate is used to enhance 19F nuclear magnetisation in 3-fluorotyrosine by more than an order of magnitude with a corresponding increase in the amplitudes of 19F–1H cross-relaxation and cross-correlation effects. The reactions employed are cyclic and leave the sample chemically unchanged. The potential for enhancing the sensitivity of heteronuclear NOEs in 19F-labelled proteins is discussed.

Item Type:Article
Additional Information:
Keywords:NMR, CIDNP, NOE, Fluorine, Amino acid.
Full text:Full text not available from this repository.
Publisher Web site:http://dx.doi.org/10.1016/j.jmr.2004.01.011
Record Created:16 Jan 2008
Last Modified:08 Apr 2009 16:36

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