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Synthesis of 5'-Amino-5'-deoxyguanosine-5'-N-phosphoramidate and its enzymatic Incorporation at the 5'-termini of RNA molecules.

Williamson, D. and Cann, M. J. and Hodgson, D. R. W. (2007) 'Synthesis of 5'-Amino-5'-deoxyguanosine-5'-N-phosphoramidate and its enzymatic Incorporation at the 5'-termini of RNA molecules.', Chemical communications., 47 . pp. 5096-5098.

Abstract

5-Amino-5-deoxyguanosine-5-N-phosphoramidate (GNHP) was synthesized in four steps from guanosine and was found to initiate T7 RNAP-promoted transcriptions to afford 5-H2N-RNA that can be conjugated to activated esters.

Item Type:Article
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Full text:Full text not available from this repository.
Publisher Web site:http://dx.doi.org/10.1039/b712066d
Record Created:18 Jan 2008
Last Modified:08 Apr 2009 16:37

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