A.S. Raghunath
Symptoms in patients on long-term proton pump inhibitors: prevalance and predictors
Raghunath, A.S.; Hungin, A.P.; Mason, J.; Jackson, W.
Authors
A.P. Hungin
J. Mason
W. Jackson
Abstract
Background Symptom control in primary care patients on long-term proton pump inhibitor (PPI) treatment is poorly understood. Aim To explore associations between symptom control and demographics, lifestyle, PPI use, diagnosis and Helicobacter pylori status. Methods A cross-sectional survey (n = 726) using note reviews, questionnaires and carbon-13 urea breath testing. Determinants of symptom control [Leeds Dyspepsia Questionnaire (LDQ), Carlsson and Dent Reflux Questionnaire (CDRQ), health-related quality-of-life measures (EuroQoL: EQ-5D and EQ-VAS)] were explored using stepwise linear regression. Results Moderate or severe dyspepsia symptoms occurred in 61% of subjects (LDQ) and reflux symptoms in 59% (CDRQ). Age, gender, smoking and body mass index had little or no influence upon symptom control or PPI use. Average symptom scores and PPI use were lower in patients with non-ulcer dyspepsia and gastro-protection than gastro-oesophageal reflux disease (GERD) and uninvestigated dyspepsia. H. pylori infection was associated with lower reflux symptom scores only in patients with GERD and uninvestigated dyspepsia. EQ-5D was not able to discriminate between diagnostic groups, although the EQ-VAS performed well. Conclusions A majority of patients suffered ongoing moderate or severe symptoms. GERD and uninvestigated dyspepsia were associated with poorer long-term symptom control; H. pylori appeared to have a protective effect on reflux symptoms in these patients.
Citation
Raghunath, A., Hungin, A., Mason, J., & Jackson, W. (2009). Symptoms in patients on long-term proton pump inhibitors: prevalance and predictors. Alimentary Pharmacology and Therapeutics, 29(4), 431-439. https://doi.org/10.1111/j.1365-2036.2008.03897.x
Journal Article Type | Article |
---|---|
Publication Date | Feb 1, 2009 |
Deposit Date | Apr 27, 2009 |
Journal | Alimentary Pharmacology and Therapeutics |
Print ISSN | 0269-2813 |
Electronic ISSN | 1365-2036 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 29 |
Issue | 4 |
Pages | 431-439 |
DOI | https://doi.org/10.1111/j.1365-2036.2008.03897.x |
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