Professor Paul Denny p.w.denny@durham.ac.uk
Professor
Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite
Denny, PW; Morgan, GW; Field, MC; Smith, DF
Authors
GW Morgan
MC Field
DF Smith
Abstract
To investigate the role of clathrin-mediated trafficking during the Leishmania lifecycle, open reading frames encoding clathrin heavy chain and the β-adaptins, major components of the adaptor complexes, have been analysed both in silico and experimentally. The Leishmania genome encodes three β-adaptins, which arose at a time predating speciation of these divergent trypanosomatids. Unlike Trypanosoma brucei, both clathrin heavy chain and β-adaptin1 are constitutively expressed throughout the Leishmania life cycle. Clathrin relocalises in amastigotes relative to promastigotes, consistent with developmental alterations to the morphology of the endo-membrane system.
Citation
Denny, P., Morgan, G., Field, M., & Smith, D. (2005). Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite. Experimental Parasitology, 109(1), 33-37. https://doi.org/10.1016/j.exppara.2004.10.007
Journal Article Type | Article |
---|---|
Publication Date | Jan 1, 2005 |
Deposit Date | May 11, 2009 |
Journal | Experimental Parasitology |
Print ISSN | 0014-4894 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 109 |
Issue | 1 |
Pages | 33-37 |
DOI | https://doi.org/10.1016/j.exppara.2004.10.007 |
Keywords | Leishmania, Kinetoplastid, Intra-macrophage parasite, Clathrin, Adaptin, Evolution, Trafficking, Protein complex, Parasitophorous vacuoles, Mediated endocytosis, Trypanosoma-brucei, Macrophages, Amazonensis, Protozoan, Molecules, Mexicana, System. |
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