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Leishmania major : clathrin and adaptin complexes of an intra-cellular parasite.

Denny, P. W. and Morgan, G. W. and Field, M. C. and Smith, D. F. (2005) 'Leishmania major : clathrin and adaptin complexes of an intra-cellular parasite.', Experimental parasitology., 109 (1). pp. 33-37.


To investigate the role of clathrin-mediated trafficking during the Leishmania lifecycle, open reading frames encoding clathrin heavy chain and the β-adaptins, major components of the adaptor complexes, have been analysed both in silico and experimentally. The Leishmania genome encodes three β-adaptins, which arose at a time predating speciation of these divergent trypanosomatids. Unlike Trypanosoma brucei, both clathrin heavy chain and β-adaptin1 are constitutively expressed throughout the Leishmania life cycle. Clathrin relocalises in amastigotes relative to promastigotes, consistent with developmental alterations to the morphology of the endo-membrane system.

Item Type:Article
Keywords:Leishmania, Kinetoplastid, Intra-macrophage parasite, Clathrin, Adaptin, Evolution, Trafficking, Protein complex, Parasitophorous vacuoles, Mediated endocytosis, Trypanosoma-brucei, Macrophages, Amazonensis, Protozoan, Molecules, Mexicana, System.
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Record Created:11 May 2009 11:05
Last Modified:09 Jun 2009 15:52

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