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The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system

Morgan, GW; Hall, BS; Denny, PW; Field, MC; Carrington, M

Authors

GW Morgan

BS Hall

MC Field

M Carrington



Abstract

Endocytic systems within eukaryotic cells are a diverse set of intracellular transport pathways responsible for uptake, recycling, interaction with the exocytic system and degradation of molecules. Each of these pathways requires the interaction of distinct protein components that function in macromolecule sorting, control of transport rates and in membrane biogenesis. In the second of two articles on kinetoplastida endocytosis, the endocytic system in Trypanosoma brucei is considered as a model, and the molecules that control this system and the protein components of the endocytic pathway are discussed. We also consider novel mechanisms for sorting that have been proposed to operate in trypanosomes.

Citation

Morgan, G., Hall, B., Denny, P., Field, M., & Carrington, M. (2002). The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system. Trends in Parasitology, 18(12), 540-546. https://doi.org/10.1016/s1471-4922%2802%2902392-9

Journal Article Type Article
Publication Date Dec 1, 2002
Deposit Date May 11, 2009
Journal Trends in Parasitology
Print ISSN 1471-4922
Publisher Cell Press
Peer Reviewed Peer Reviewed
Volume 18
Issue 12
Pages 540-546
DOI https://doi.org/10.1016/s1471-4922%2802%2902392-9
Keywords Lysosomal membrane glycoprotein, Trypanosoma-brucei-rhodesiense, GPI-anchored proteins, African trypanosomes, Mediated endocytosis, Molecular-cloning, Fagellar pocket, Surface protein, RAB11 homolog, Cell-surface.


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