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The endocytic apparatus of the kinetoplastida : Part II : machinery and components of the system.

Morgan, G. W. and Hall, B. S. and Denny, P. W. and Field, M. C. and Carrington, M. (2002) 'The endocytic apparatus of the kinetoplastida : Part II : machinery and components of the system.', Trends in parasitology., 18 (12). pp. 540-546.


Endocytic systems within eukaryotic cells are a diverse set of intracellular transport pathways responsible for uptake, recycling, interaction with the exocytic system and degradation of molecules. Each of these pathways requires the interaction of distinct protein components that function in macromolecule sorting, control of transport rates and in membrane biogenesis. In the second of two articles on kinetoplastida endocytosis, the endocytic system in Trypanosoma brucei is considered as a model, and the molecules that control this system and the protein components of the endocytic pathway are discussed. We also consider novel mechanisms for sorting that have been proposed to operate in trypanosomes.

Item Type:Article
Keywords:Lysosomal membrane glycoprotein, Trypanosoma-brucei-rhodesiense, GPI-anchored proteins, African trypanosomes, Mediated endocytosis, Molecular-cloning, Fagellar pocket, Surface protein, RAB11 homolog, Cell-surface.
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Record Created:11 May 2009 11:20
Last Modified:09 Jun 2009 15:50

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